Human HERC6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HERC6
Locus ID	55008
Kit Components	GA110447G1, HERC6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110447G2, HERC6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110447G3, HERC6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001013000, NM_001013002, NM_001013005, NM_001165136, NM_017912
Synonyms	FLJ20637; hect domain and RLD 6; potential ubiquitin ligase
Summary	HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

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