Human PAK1 interacting protein 1 (PAK1IP1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PAK1IP1
Locus ID	55003
Kit Components	GA110442G1, PAK1 interacting protein 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110442G2, PAK1 interacting protein 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110442G3, PAK1 interacting protein 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_017906
Synonyms	bA421M1.5; hPIP1; MAK11; PIP1; WDR84
Summary	Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).[UniProtKB/Swiss-Prot Function]

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