Human IRAK4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IRAK4
Locus ID	51135
Kit Components	GA109597G1, IRAK4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109597G2, IRAK4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109597G3, IRAK4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001114182, NM_001145256, NM_001145257, NM_001145258, NM_016123, NM_001351338, NM_001351339, NM_001351340, NM_001351341, NM_001351342, NM_001351343, NM_001351344, NM_001351345
Synonyms	IPD1; IRAK-4; NY-REN-64; REN64
Summary	This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

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