Human HA1 (ARHGAP45) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARHGAP45
Locus ID	23526
Kit Components	GA108369G1, HA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108369G2, HA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108369G3, HA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001258328, NM_001282334, NM_001282335, NM_001321232, NM_012292, NR_047652
Synonyms	HA-1; HLA-HA1; HMHA1
Summary	Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.[UniProtKB/Swiss-Prot Function]

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