Human SASH1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SASH1
Locus ID	23328
Kit Components	GA108223G1, SASH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108223G2, SASH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108223G3, SASH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_015278, NM_001346505, NM_001346506, NM_001346507, NM_001346508, NM_001346509
Synonyms	dJ323M4; dJ323M4.1; SH3D6A
Summary	This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]

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