Human DNAJB4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DNAJB4
Locus ID	11080
Kit Components	GA107618G1, DNAJB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107618G2, DNAJB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107618G3, DNAJB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001317099, NM_001317100, NM_001317101, NM_001317102, NM_001317103, NM_007034
Synonyms	DjB4; DNAJW; HLJ1
Summary	The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

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