Human LIAS activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LIAS
Locus ID	11019
Kit Components	GA107569G1, LIAS gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107569G2, LIAS gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107569G3, LIAS gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001278590, NM_001278591, NM_001278592, NM_006859, NM_194451, NM_001363700
Synonyms	HGCLAS; HUSSY-01; LAS; LIP1; LS; PDHLD
Summary	The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020]

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.