Human JAB1 (COPS5) activation kit by CRISPRa

CAT#: GA107543

COPS5 CRISPRa kit - CRISPR gene activation of human COP9 signalosome subunit 5



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
COPS5 (JAB1) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


COPS5 (Myc-DDK-tagged)-Human COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5)
    • 10 ug

CNY 3,656.00
CNY 3,990.00


COPS5 (JAB1) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol COPS5
Locus ID 10987
Kit Components

GA107543G1, JAB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107543G2, JAB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107543G3, JAB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_006837
Synonyms CSN5; JAB1; MOV-34; SGN5
Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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