Human FRS2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FRS2
Locus ID	10818
Kit Components	GA107417G1, FRS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107417G2, FRS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107417G3, FRS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001042555, NM_001278351, NM_001278353, NM_001278354, NM_001278355, NM_001278356, NM_001278357, NM_006654
Synonyms	FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
Summary	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.[UniProtKB/Swiss-Prot Function]

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