Human ATP dependent metalloprotease YME1L1 (YME1L1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	YME1L1
Locus ID	10730
Kit Components	GA107351G1, ATP dependent metalloprotease YME1L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107351G2, ATP dependent metalloprotease YME1L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107351G3, ATP dependent metalloprotease YME1L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001253866, NM_014263, NM_139312, NM_139313
Synonyms	FTSH; MEG4; PAMP; YME1L
Summary	The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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