Human GABA B Receptor 2 (GABBR2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GABBR2
Locus ID	9568
Kit Components	GA106405G1, GABA B Receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106405G2, GABA B Receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106405G3, GABA B Receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005458
Synonyms	GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
Summary	The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]

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