Human Macrophage Inflammatory Protein 1 beta (CCL4L2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CCL4L2
Locus ID	9560
Kit Components	GA106400G1, Macrophage Inflammatory Protein 1 beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106400G2, Macrophage Inflammatory Protein 1 beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106400G3, Macrophage Inflammatory Protein 1 beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001001435, NM_001291468, NM_001291469, NM_001291470, NM_001291471, NM_001291472, NM_001291473, NM_001291474, NM_001291475, NR_111970
Synonyms	AT744.2; CCL4L; LAG-1; LAG1; SCYA4L
Summary	This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

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