Human PDE5A activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDE5A
Locus ID	8654
Kit Components	GA105736G1, PDE5A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105736G2, PDE5A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105736G3, PDE5A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001083, NM_033430, NM_033431, NM_033437
Synonyms	CGB-PDE; CN5A; PDE5
Summary	This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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