Human MAP2K1IP1 (LAMTOR3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LAMTOR3
Locus ID	8649
Kit Components	GA105732G1, MAP2K1IP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105732G2, MAP2K1IP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105732G3, MAP2K1IP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001243736, NM_021970, NR_024170
Synonyms	MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3
Summary	This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

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