Human RASSF7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RASSF7
Locus ID	8045
Kit Components	GA105394G1, RASSF7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105394G2, RASSF7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105394G3, RASSF7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001143993, NM_001143994, NM_003475
Synonyms	C11orf13; HRAS1; HRC1
Summary	Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.[UniProtKB/Swiss-Prot Function]

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