Human TM7SF1 (GPR137B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GPR137B
Locus ID	7107
Kit Components	GA104908G1, TM7SF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104908G2, TM7SF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104908G3, TM7SF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003272
Synonyms	TM7SF1
Summary	Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).[UniProtKB/Swiss-Prot Function]

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