Human TLE 1 (TLE1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TLE1
Locus ID	7088
Kit Components	GA104889G1, TLE 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104889G2, TLE 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104889G3, TLE 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001303103, NM_001303104, NM_005077
Synonyms	ESG; ESG1; GRG1
Summary	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.[UniProtKB/Swiss-Prot Function]

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