Human Tyrosine Hydroxylase (TH) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TH
Locus ID	7054
Kit Components	GA104861G1, Tyrosine Hydroxylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104861G2, Tyrosine Hydroxylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104861G3, Tyrosine Hydroxylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000360, NM_199292, NM_199293
Synonyms	DYT5b; DYT14; TYH
Summary	The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

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