Human SorLA (SORL1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SORL1
Locus ID	6653
Kit Components	GA104563G1, SorLA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104563G2, SorLA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104563G3, SorLA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003105
Synonyms	C11orf32; gp250; LR11; LRP9; SORLA; SorLA-1
Summary	This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]

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