Human EAAT2 (SLC1A2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SLC1A2
Locus ID	6506
Kit Components	GA104431G1, EAAT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104431G2, EAAT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104431G3, EAAT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001195728, NM_001252652, NM_004171
Synonyms	EAAT2; GLT-1; HBGT
Summary	This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

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