Human epithelial Sodium Channel alpha (SCNN1A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SCNN1A
Locus ID	6337
Kit Components	GA104302G1, epithelial Sodium Channel alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104302G2, epithelial Sodium Channel alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104302G3, epithelial Sodium Channel alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001038, NM_001159575, NM_001159576
Synonyms	BESC2; ENaCa; ENaCalpha; SCNEA; SCNN1
Summary	Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]

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