Human RAB3A activation kit by CRISPRa

CAT#: GA103978

RAB3A CRISPRa kit - CRISPR gene activation of human RAB3A, member RAS oncogene family



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
RAB3A mouse monoclonal antibody,clone OTI1G3
    • 100 ul

CNY 1,999.00
CNY 2,700.00


RAB3A (Myc-DDK-tagged)-Human RAB3A, member RAS oncogene family (RAB3A)
    • 10 ug

CNY 2,400.00
CNY 3,705.00


RAB3A mouse monoclonal antibody,clone OTI5C12
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol RAB3A
Locus ID 5864
Kit Components

GA103978G1, RAB3A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103978G2, RAB3A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103978G3, RAB3A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_002866
Summary Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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