Human PTP epsilon (PTPRE) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PTPRE
Locus ID	5791
Kit Components	GA103935G1, PTP epsilon gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103935G2, PTP epsilon gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103935G3, PTP epsilon gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001316676, NM_001316677, NM_006504, NM_130435, NM_001323354, NM_001323355, NM_001323356, NM_001323357
Synonyms	HPTPE; PTPE; R-PTP-EPSILON
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]

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