Human Proteasome subunit alpha type 6 (PSMA6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PSMA6
Locus ID	5687
Kit Components	GA103856G1, Proteasome subunit alpha type 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103856G2, Proteasome subunit alpha type 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103856G3, Proteasome subunit alpha type 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282232, NM_001282233, NM_001282234, NM_002791, NR_104110
Synonyms	IOTA; p27K; PROS27
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

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