Human PPM1B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PPM1B
Locus ID	5495
Kit Components	GA103701G1, PPM1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103701G2, PPM1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103701G3, PPM1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033556, NM_001033557, NM_002706, NM_177968, NM_177969
Synonyms	PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
Summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

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