Human PLP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLP1
Locus ID	5354
Kit Components	GA103612G1, PLP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103612G2, PLP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103612G3, PLP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000533, NM_001128834, NM_001305004, NM_199478
Synonyms	GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; SPG2
Summary	This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]

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