Human PDE3B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDE3B
Locus ID	5140
Kit Components	GA103437G1, PDE3B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103437G2, PDE3B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103437G3, PDE3B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000922, NM_001363569, NM_001363570
Synonyms	cGIPDE1; HcGIP1
Summary	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.[UniProtKB/Swiss-Prot Function]

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