Human PDE1A activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDE1A
Locus ID	5136
Kit Components	GA103433G1, PDE1A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103433G2, PDE1A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103433G3, PDE1A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001003683, NM_001258312, NM_001258313, NM_001258314, NM_005019, NM_001363871
Synonyms	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A
Summary	Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

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