Human PAX3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PAX3
Locus ID	5077
Kit Components	GA103391G1, PAX3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103391G2, PAX3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103391G3, PAX3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000438, NM_001127366, NM_013942, NM_181457, NM_181458, NM_181459, NM_181460, NM_181461
Synonyms	CDHS; HUP2; WS1; WS3
Summary	This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]

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