Human Natriuretic Peptide Receptor B (NPR2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NPR2
Locus ID	4882
Kit Components	GA103259G1, Natriuretic Peptide Receptor B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103259G2, Natriuretic Peptide Receptor B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103259G3, Natriuretic Peptide Receptor B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000907, NM_003995
Synonyms	AMDM; ANPRB; GUC2B; GUCY2B; NPRB; NPRBi
Summary	This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

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