Human Ataxin 3 (ATXN3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATXN3
Locus ID	4287
Kit Components	GA102914G1, Ataxin 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102914G2, Ataxin 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102914G3, Ataxin 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001024631, NM_001127696, NM_001127697, NM_001164774, NM_001164775, NM_001164776, NM_001164777, NM_001164778, NM_001164779, NM_001164780, NM_001164781, NM_001164782, NM_004993, NM_030660, NR_028453, NR_028454, NR_028455, NR_028456, NR_028457, NR_028458, NR_028459, NR_028460, NR_028461, NR_028462, NR_028463, NR_028464, NR_028465, NR_028466, NR_028467, NR_028468, NR_028469, NR_028470, NR_031765
Synonyms	AT3; ATX3; JOS; MJD; MJD1; SCA3
Summary	Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2016]

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