Human Ataxin 3 (ATXN3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATXN3
Locus ID	4287
Kit Components	GA102914G1, Ataxin 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102914G2, Ataxin 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102914G3, Ataxin 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001024631, NM_001127696, NM_001127697, NM_001164774, NM_001164775, NM_001164776, NM_001164777, NM_001164778, NM_001164779, NM_001164780, NM_001164781, NM_001164782, NM_004993, NM_030660, NR_028453, NR_028454, NR_028455, NR_028456, NR_028457, NR_028458, NR_028459, NR_028460, NR_028461, NR_028462, NR_028463, NR_028464, NR_028465, NR_028466, NR_028467, NR_028468, NR_028469, NR_028470, NR_031765
Synonyms	AT3; ATX3; JOS; MJD; MJD1; SCA3
Summary	Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2016]

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