Human Inosine triphosphate pyrophosphatase (ITPA) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ITPA
Locus ID	3704
Kit Components	GA102492G1, Inosine triphosphate pyrophosphatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102492G2, Inosine triphosphate pyrophosphatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102492G3, Inosine triphosphate pyrophosphatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001267623, NM_033453, NM_181493, NR_052000, NR_052001, NR_052002, NM_001324236, NM_001324237, NM_001324238, NM_001324240, NM_001351739
Synonyms	C20orf37; dJ794I6.3; HLC14-06-P; My049
Summary	This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

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