Human CD49b (ITGA2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ITGA2
Locus ID	3673
Kit Components	GA102464G1, CD49b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102464G2, CD49b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102464G3, CD49b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002203, NR_073103, NR_073104, NR_073105, NR_073106, NR_073107
Synonyms	BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2
Summary	This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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