Human NRG1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NRG1
Locus ID	3084
Kit Components	GA102104G1, NRG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102104G2, NRG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102104G3, NRG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001159995, NM_001159996, NM_001159999, NM_001160001, NM_001160002, NM_001160004, NM_001160005, NM_001160007, NM_001160008, NM_001322197, NM_001322201, NM_001322202, NM_001322205, NM_001322206, NM_001322207, NM_004495, NM_013956, NM_013957, NM_013958, NM_013959, NM_013960, NM_013961, NM_013962, NM_013964, NM_001322203
Synonyms	ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF
Summary	The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

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