Human Folylpolyglutamate synthase (FPGS) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FPGS
Locus ID	2356
Kit Components	GA101651G1, Folylpolyglutamate synthase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101651G2, Folylpolyglutamate synthase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101651G3, Folylpolyglutamate synthase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001018078, NM_001288803, NM_004957, NR_110170
Synonyms	folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase; folylpolyglutamate synthetase; OTTHUMP00000022201; OTTHUMP00000022202; tetrahydrofolylpolyglutamate synthase
Summary	This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

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