Human Dematin (DMTN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DMTN
Locus ID	2039
Kit Components	GA101418G1, Dematin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101418G2, Dematin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101418G3, Dematin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001114135, NM_001114136, NM_001114137, NM_001114138, NM_001114139, NM_001302816, NM_001302817, NM_001978, NM_001323378, NM_001323379, NM_001323380, NM_001323381, NM_001323382, NM_001323383, NM_001323384, NM_001323385, NM_001323387, NM_001323388, NM_001323389, NM_001323390, NM_001323391, NM_001323392, NM_001323393, NM_001323394, NM_001323395, NM_001323396, NM_001323397, NM_001323398, NM_001323399, NM_001323400, NM_001323401
Synonyms	DMT; EPB49
Summary	The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

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