Human Decorin (DCN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DCN
Locus ID	1634
Kit Components	GA101151G1, Decorin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101151G2, Decorin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101151G3, Decorin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001920, NM_133503, NM_133504, NM_133505, NM_133506, NM_133507
Synonyms	CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B
Summary	This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

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