Human Cytochrome C Oxidase subunit VIc (COX6C) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	COX6C
Locus ID	1345
Kit Components	GA100937G1, Cytochrome C Oxidase subunit VIc gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100937G2, Cytochrome C Oxidase subunit VIc gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100937G3, Cytochrome C Oxidase subunit VIc gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004374
Synonyms	cytochrome c oxidase subunit VIc; cytochrome c oxidase subunit VIc preprotein
Summary	Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

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