Human p57 Kip2 (CDKN1C) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CDKN1C
Locus ID	1028
Kit Components	GA100740G1, p57 Kip2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100740G2, p57 Kip2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100740G3, p57 Kip2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000076, NM_001122630, NM_001122631, NM_001362474, NM_001362475
Synonyms	BWCR; BWS; KIP2; p57; p57Kip2; WBS
Summary	This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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