Human C18orf1 (LDLRAD4) activation kit by CRISPRa
CAT#: GA100522
LDLRAD4 CRISPRa kit - CRISPR gene activation of human low density lipoprotein receptor class A domain containing 4
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | LDLRAD4 |
Locus ID | 753 |
Kit Components | GA100522G1, C18orf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100522G2, C18orf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100522G3, C18orf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001003674, NM_001003675, NM_001276249, NM_001276251, NM_004338, NM_181481, NM_181482, NM_181483, N48737, N63974 |
Synonyms | C18orf1 |
Summary | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN413492 | LDLRAD4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
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