Human BLM activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BLM
Locus ID	641
Kit Components	GA100438G1, BLM gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100438G2, BLM gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100438G3, BLM gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000057, NM_001287246, NM_001287247, NM_001287248
Synonyms	BS; RECQ2; RECQL2; RECQL3
Summary	The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. [provided by RefSeq, May 2020]

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