Human ATP6AP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATP6AP1
Locus ID	537
Kit Components	GA100372G1, ATP6AP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100372G2, ATP6AP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100372G3, ATP6AP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001183
Synonyms	16A; Ac45; ATP6IP1; ATP6S1; CF2; VATPS1; XAP-3; XAP3
Summary	This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

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