Human ATIC activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATIC
Locus ID	471
Kit Components	GA100328G1, ATIC gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100328G2, ATIC gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100328G3, ATIC gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004044
Synonyms	AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
Summary	This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

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