Human Steroid sulfatase (STS) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	STS
Locus ID	412
Kit Components	GA100301G1, Steroid sulfatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100301G2, Steroid sulfatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100301G3, Steroid sulfatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000351, NM_001320750, NM_001320751, NM_001320752, NM_001320753, NM_001320754
Synonyms	ARSC; ARSC1; ASC; ES; SSDD; XLI
Summary	This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

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