Human Steroid sulfatase (STS) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	STS
Locus ID	412
Kit Components	GA100301G1, Steroid sulfatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100301G2, Steroid sulfatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100301G3, Steroid sulfatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000351, NM_001320750, NM_001320751, NM_001320752, NM_001320753, NM_001320754
Synonyms	ARSC; ARSC1; ASC; ES; SSDD; XLI
Summary	This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

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