Human HIF1 beta (ARNT) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARNT
Locus ID	405
Kit Components	GA100294G1, HIF1 beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100294G2, HIF1 beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100294G3, HIF1 beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001197325, NM_001286035, NM_001286036, NM_001668, NM_178426, NM_178427, NM_001350224, NM_001350225, NM_001350226
Synonyms	bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Summary	This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

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