Human Ankyrin brain (ANK2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ANK2
Locus ID	287
Kit Components	GA100200G1, Ankyrin brain gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100200G2, Ankyrin brain gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100200G3, Ankyrin brain gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001127493, NM_001148, NM_020977, NM_001354225, NM_001354228, NM_001354230, NM_001354231, NM_001354232, NM_001354235, NM_001354236, NM_001354237, NM_001354239, NM_001354240, NM_001354241, NM_001354242, NM_001354243, NM_001354244, NM_001354245, NM_001354246, NM_001354249, NM_001354252, NM_001354253, NM_001354254, NM_001354255, NM_001354256, NM_001354257, NM_001354258, NM_001354260, NM_001354261, NM_001354262, NM_001354264, NM_001354265, NM_001354266, NM_001354267, NM_001354268, NM_001354269, NM_001354270, NM_001354271, NM_001354272, NM_001354273, NM_001354274, NM_001354275, NM_001354276, NM_001354277, NM_001354278, NM_001354279, NM_001354280, NM_001354281, NM_001354282
Synonyms	ANK-2; brank-2; LQT4
Summary	This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]

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