Human alpha 2 Macroglobulin (A2M) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	A2M
Locus ID	2
Kit Components	GA100002G1, alpha 2 Macroglobulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100002G2, alpha 2 Macroglobulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100002G3, alpha 2 Macroglobulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000014, NM_001347423, NM_001347424, NM_001347425
Synonyms	A2MD; CPAMD5; FWP007; S863-7
Summary	The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

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