Sema5a (NM_001107659) Rat Tagged ORF Clone Lentiviral Particle
CAT#: RR208579L3V
- LentiORF®
Lenti ORF particles, Sema5a (Myc-DDK-tagged ORF) - Rat sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (Sema5a), 200ul, >10^7 TU/mL
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CNY 19,124.00
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Specifications
Product Data | |
Product Name | Sema5a (NM_001107659) Rat Tagged ORF Clone Lentiviral Particle |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001107659 |
ORF Size | 3222 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RR208579).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001107659.2, NP_001101129.1 |
RefSeq Size | 10501 bp |
RefSeq ORF | 3225 bp |
Locus ID | 310207 |
Gene Summary | Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.[UniProtKB/Swiss-Prot Function] |
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