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C19orf46 (SYNE4) (NM_001039876) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC223193L3V
- LentiORF®
-
Lenti ORF particles, SYNE4 (Myc-DDK tagged) - Human chromosome 19 open reading frame 46 (C19orf46), 200ul, >10^7 TU/mL
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CNY 8,455.00
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Specifications
| Product Data | |
| Product Name | C19orf46 (SYNE4) (NM_001039876) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | C19orf46; DFNB76; KASH4; Nesp4 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001039876 |
| ORF Size | 1212 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC223193).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001039876.1 |
| RefSeq Size | 1541 bp |
| RefSeq ORF | 1215 bp |
| Locus ID | 163183 |
| Protein Families | Transmembrane |
| MW | 43.3 kDa |
| Gene Summary | This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
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