53BP1 (TP53BP1) (NM_005657) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC218016L1V
- LentiORF®
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Lenti ORF particles, TP53BP1 (Myc-DDK tagged) - Human tumor protein p53 binding protein 1 (TP53BP1), transcript variant 3, 200ul, >10^7 TU/mL
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CNY 21,660.00
Cited in 1 publication. |
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CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | 53BP1 (TP53BP1) (NM_005657) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | 53BP1; p53BP1; p202; TDRD30 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_005657 |
ORF Size | 5916 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC218016).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_005657.1 |
RefSeq Size | 6266 bp |
RefSeq ORF | 5919 bp |
Locus ID | 7158 |
Domains | BRCT |
Protein Families | Druggable Genome, Transcription Factors |
MW | 213.4 kDa |
Gene Summary | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
,null,
Molecular cell
,PubMed ID 34216544
[TP53BP1]
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